Chemotherapy can induce cold pains. How ‘brain circuit’ causing it was found

Researchers from the Indian Institute of Science (IISc), Bengaluru, and TCG-CREST, Kolkata, have identified a specific 'brain circuit' responsible for 'cold allodynia,' a painful side effect of chemotherapy, particularly from the drug oxaliplatin. Published in 'Cell Reports,' the study, primarily conducted on mice, pinpointed the connection between the lateral parabrachial nucleus and the parafascicular region of the thalamus as crucial. This discovery aims to pave the way for pharmacological interventions to alleviate chronic pain in chemotherapy patients.