Statement 1 is incorrect. While genetic factors can contribute to susceptibility to infections, they are not directly related to the occurrence of multi-drug resistance in microbial pathogens. Statement 2 is correct. Incorrect use of antibiotics, including taking incorrect doses or not completing the full course of treatment, can contribute to the development of drug resistance in microbial pathogens. Statement 3 is correct. The widespread use of antibiotics in livestock farming can lead to the development of drug-resistant pathogens that can affect both animals and humans. Statement 4 is incorrect. While individuals with chronic diseases may be more susceptible to infections, this factor is not directly related to the occurrence of multi-drug resistance in microbial pathogens.